Therapeutic Role of Resveratrol and Piceatannol in Disease Prevention

نویسندگان

  • Aayush Kukreja
  • Neha Wadhwa
  • Archana Tiwari
چکیده

Polyphenols are abundant micronutrients that complement and add to the functions of antioxidants, vitamins and enzymes as a defense against oxidative stress caused by excess reactive oxygen species. They contain phenolic rings in their structure and are found in different forms in nature. These compounds are classified into different groups on the basis of the number of phenol rings that they contain and structural elements that are attached to these rings (Figure 1) [1,2].

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Glycobiology Insights Synthesis of Glycosides of Resveratrol, Pterostilbene, and Piceatannol by Glucosyltransferase from Phytolacca americana Expressed in Bacillus subtilis and their Chemopreventive Activity Against Cancer, Allergic, and Alzheimer’s Diseases

ABSTR ACT: Resveratrol was glucosylated to its 3and 4′-β-glucosides by the glucosyltransferase PaGT3 from Phytolacca americana expressed in Bacillus subtilis. PaGT3 glucosylated pterostilbene to its 4′-β-glucoside. Piceatannol was converted into its 4′-β-glucoside by PaGT3. Resveratrol 3-β-glucoside showed the inhibitory action of adhesion, migration, and invasion of KB cells. The resveratrol 3...

متن کامل

Piceatannol lowers the blood glucose level in diabetic mice.

We previously found that passion fruit (Passiflora edulis) seeds contained a high amount of piceatannol (3,5,3',4'-trans-tetrahydroxystilbene), a natural analog of resveratrol (3,5,4'-trans-trihydroxystilbene). Resveratrol has been proposed as a potential anti-metabolic disorder compound, by its activation of sirtuin and AMP-activated protein kinase. Many reports show that resveratrol ameliorat...

متن کامل

Piceatannol and Its Metabolite, Isorhapontigenin, Induce SIRT1 Expression in THP-1 Human Monocytic Cell Line

Piceatannol is a phytochemical that is present in large amounts in passion fruit (Passiflora edulis) seeds, and is an analog of resveratrol. Recently, the absorption and metabolism of piceatannol were investigated in rats, and isorhapontigenin, O-methyl piceatannol, was detected as a piceatannol metabolite in rat plasma. To elucidate the function of piceatannol and its metabolites, we investiga...

متن کامل

اثرات ضد سرطانی رزوراترول بر سرطان پستان

Breast cancer is the most common cancer in women worldwide. Current cancer treatments have multiple side effects, including damage to healthy cells, drug resistance and disease recurrence. Therefore, new therapeutic strategies are needed to achieve fewer toxicity and side effects. Several studies suggest that phytochemicals could be considered as appropriate choices for cancer prevention and...

متن کامل

Resveratrol-induced modification of polyamine metabolism is accompanied by induction of c-Fos.

The objective of the current study was to investigate the effect of resveratrol, a naturally occurring polyphenol with cancer chemopreventive properties, on polyamine metabolism in the human colonic adenocarcinoma cell line Caco-2. We demonstrated that inhibition of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis, was due to attenuated ODC protein and mRNA leve...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2014